What is CAS number 9049 76 7?

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Hydroxypropyl starch plays a significant role in scientific research applications. It contributes to the exploration of starch's structure, properties, and interactions with other substances. Furthermore, it aids in investigating the impact of starch modification on the absorption and digestibility of nutrients. Additionally, Hydroxypropyl starch ether facilitates the study of how starch modification affects texture and structure.

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1.Preparation and physicochemical properties of three types of modified glutinous rice starches.

Yang L1, Zhou Y2, Wu Y1, Meng X1, Jiang Y1, Zhang H1, Wang H1. Carbohydr Polym. Feb 10;137:305-13. doi: 10./j.carbpol..10.065. Epub Oct 20.

Hydroxypropylated, phosphorylated, and hydroxypropyl-phosphorylated starches were prepared from glutinous rice starch, and their physicochemical and structural properties were investigated. With increasing reaction time, the molar or degree of substitution of modified starches increased. SEM micrographs revealed that phosphorylated starch granules retained their relative integrity, while some cracks appeared on the surface of hydroxypropylated and hydroxypropyl-phosphorylated starch granules. RVA analyses revealed that pasting properties improved after chemical modification. Chemical modification improved freeze-thaw stability, especially in hydroxypropyl-phosphorylated starch. DSC analyses showed that onset temperature and gelatinization enthalpy decreased with increasing reaction time, especially in the dual-modified starch. X-ray diffraction patterns revealed that native and modified starches had A-type crystalline patterns.

2.Inclusion complexation of pinostrobin with various cyclodextrin derivatives.

Kicuntod J1, Khuntawee W2, Wolschann P3, Pongsawasdi P4, Chavasiri W5, Kungwan N6, Rungrotmongkol T7. J Mol Graph Model. Jan;63:91-8. doi: 10./j.jmgm..11.005. Epub Nov 12.

Pinostrobin (PNS) is one of the important flavonoids and can be abundantly found in the rhizomes of fingerroot (Boesenbergia rotrunda) and galangal (Alpinia galangal and Alpinia officinarum), the herbal basis of Southeast Asian cooking. Similar to other flavonoids, PNS exhibits anti-oxidative, anti-inflammatory and anti-cancer properties. However, this compound has an extremely low water solubility that limits its use in pharmaceutical applications. Beta-cyclodextrin (βCD) and its derivatives, 2,6-dimethyl-βCD (2,6-DMβCD) and the three hydroxypropyl-βCDs (2-HPβCD, 6-HPβCD and 2,6-DHPβCD), have unique properties that enhance the stability and solubility of such low-soluble guest molecules. In the present study, molecular dynamics simulations were applied to investigate the dynamics and stability of PNS inclusion complexes with βCD and its derivatives (2,6-DMβCD, 2,6-DHPβCD, 2-HPβCD and 6-HPβCD). PNS was able to form complexes with βCD and all four of its derivatives by either the chromone (C-PNS) or phenyl (P-PNS) ring dipping toward the cavity.

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3.[Determination of contact angle of pharmaceutical excipients and regulating effect of surfactants on their wettability].

Hua DD, Li HR, Yang BX, Song LN, Liu TT, Cong YT, Li SM. Yao Xue Xue Bao. Oct;50(10):-5.

To study the effects of surfactants on wettability of excipients, the contact angles of six types of surfactants on the surface of two common excipients and mixture of three surfactants with excipients were measured using hypsometry method. The results demonstrated that contact angle of water on the surface of excipients was associated with hydrophilicity of excipients. Contact angle decreased with increase of hydrophilic groups of excipient molecules. The sequence of contact angle from small to large was starch < sodium benzoate < polyvinylpyrrolidone < sodium carboxymethylcellulose < sodium alginate < chitosan < hydroxypropyl methyl cellulose < magnesium stearate. Additionally, surfactants both in droplets and mixed in excipients significantly reduced the contact angle of excipients, and their abilities to lower contact angle varied. The results of the present study offer a guideline in the formulation design of tablets.

4.Complexation of a 1-Indanone Thiosemicarbazone with Hydroxypropyl-β-Cyclodextrin Enhances Its Activity Against a Hepatitis C Virus Surrogate Model.

Glisoni RJ, Castro EF, Cavallaro LV, Moglioni AG, Sosnik A. J Nanosci Nanotechnol. Jun;15(6):-8.

The current standard of care of the infection by hepatitis C virus (HCV) is effective in a limited number of patients and the high cost hinders therapy affordability and compliance. In this context, the research of new direct-acting antiviral agents (DAAs) for a more effective and long-lasting therapy is an urgent need and an area of active investigation. In an effort to develop novel DAAs, a series of 1-indanone thiosemicarbazones (TSCs) was synthesized and fully characterized. However, the high self-aggregation tendency and extremely poor aqueous solubility of these antiviral candidates often preclude their reliable biological evaluation in vitro. To maintain constant TSC concentrations over the biological assays, different TSC/cyclodextrin complexes were produced. In the present work, we report for the first time the cytotoxicity and antiviral activity of 5,6-dimethoxy TSC inclusion complexes with hydroxypropyl-β-cyclodextrin on bovine viral diarrhea virus (BVDV) as HCV surrogate model.

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